Is Opdivo chemotherapy or immunotherapy?

OPDIVO is an immunotherapy treatment. It’s a type of medicine that works with your immune system.

What is the drug nivolumab?

Listen to pronunciation. (nih-VOL-yoo-mab) A drug that binds to the protein PD-1 to help immune cells kill cancer cells better and is used to treat many different types of cancer. These include cancers that express the protein PD-L1 or that have certain mutations (changes) in genes involved in DNA repair.

What type of drug is ipilimumab?

Ipilimumab injection is in a class of medications called monoclonal antibodies. It works by helping the body to slow or stop the growth of cancer cells.

Is there a generic for Opdivo?

Generic Name: nivolumab It works by changing the action of your own immune system, directing it to attack cancer cells.

How long will Opdivo extend life?

Researchers conducted follow-up for a median of 8.4 months in the Opdivo plus Yervoy group, 9.9 months in the Opdivo alone group and 9.1 months in the placebo group. During follow-up, overall survival was a median of 9.2 months with Opdivo plus Yervoy, 10.4 months with Opdivo and 9.6 months with placebo.

How much does nivolumab cost?

The use of nivolumab alone would cost $103,220, and ipilimumab alone, which yielded a median duration of remission of <3. months, would cost $158,252. Rounding this up to approximately $300,000 for an individual patient with a 20% copay, Dr Saltz determined that the patient’s out-of-pocket cost would total $60,000.

How successful is nivolumab?

Findings: Across all four studies, 4-year overall survival with nivolumab was 14% (95% CI 11-17) for all patients (n=664), 19% (15-24) for those with at least 1% PD-L1 expression, and 11% (7-16) for those with less than 1% PD-L1 expression.

What is ipilimumab approved for?

Ipilimumab is used as adjuvant therapy in patients who have had surgery to remove melanoma in the skin and lymph nodes. Ipilimumab is used in adults and children 12 years and older whose cancer cannot be removed by surgery or has metastasized (spread to other parts of the body).

How successful is Opdivo?

Of the 49% of patients alive and in follow-up, 77% of patients who received the combination (112/145), 69% of Opdivo-treated patients (84/122) and 43% (27/63) of Yervoy-treated patients have been off treatment and never received subsequent systemic therapy.

How much longer do you live with Opdivo?

With a minimum follow-up of 6.5 years, median overall survival (OS) was 72.1 months with Opdivo plus Yervoy (95% CI: 38.2-NR), the longest reported median OS in a Phase 3 advanced melanoma trial, 36.9 months with Opdivo (95% CI: 28.2-58.7) and 19.9 months with the Yervoy group (95% CI: 16.8-24.6).

How long can you stay on Opdivo?

Your doctor will continue giving you OPDIVO for as long as you keep benefitting from it or until you no longer tolerate the treatment. Patients receiving OPDIVO after surgical removal of melanoma may require treatment for no longer than one year.

What is the success rate of nivolumab?

How long do you take nivolumab?

You have ipilimumab and nivolumab every 3 weeks for the first 4 treatments. After this, you only have nivolumab every 2 or 4 weeks. You continue treatment for as long as it’s working, and the side effects aren’t too bad.