What does HiDAC mean?
HiDAC is the abbreviation for high-dose cytarabine. Cytarabine (also called cytosine arabinidose or Ara-C) is an antimetabolite chemotherapy drug that prevents the growth or reproduction of leukaemia cells by interfering with the information of their DNA. The doses of cytarabine given.
What is MEC chemo?
The combination of MEC (mitoxantrone, etoposide, and cytarabine) is a standard treatment option, commonly used for relapsed or refractory acute myeloid leukemia.
What is HiDAC for AML?
High-dose cytarabine (HiDAC) is an established component of most treatment regimens for adult AML and is incorporated into either the induction or consolidation phase of intensive chemotherapy. HiDAC-based consolidation therapy significantly improves the survival of adult patients with AML up to the age of 60 years.
How long is a cycle of HiDAC?
HiDAC usually requires a 5-day stay in a hospital. HiDAC is repeated every 28 to 35 days. This is known as one Cycle. Each cycle may be repeated up to 3 to 4 times, depending upon the response to chemotherapy, or if the plan is to proceed with a bone marrow transplant.
What is CLAG M?
CLAG-M is typically given to patients with relapsed or refractory AML after one or more prior treatments. The goal of CLAG-M is to eliminate leukemia cells from the body and to decrease symptoms from AML, such as bleeding, bruising, and recurrent infections.
What is Leukostasis?
Leukostasis is a pathologic diagnosis in which white cell plugs are seen in the microvasculature. Clinically, leukostasis is typically diagnosed empirically when a patient with leukemia and hyperleukocytosis presents with respiratory or neurological distress.
What is CBF AML?
Core binding factor acute myeloid leukemia (CBF-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia.
What is the best medicine for leukemia?
A medicine called imatinib is now the main treatment for CML. It’s usually given soon after a diagnosis is made to slow the progression of the cancer and stop it reaching an advanced phase. Imatinib works by reducing the production of abnormal white blood cells. It’s taken as a tablet once a day.
What is CLAG therapy?
What is Leukocytapheresis?
White blood cell removal, also known as leukocytapheresis, is a nonsurgical treatment to reduce the quantity of white blood cells in your child’s bloodstream. Leukocytapheresis may be used alone or in conjunction with other treatments. White blood cells are part of the immune system. They help the body fight infection.
What causes hyperleukocytosis?
Hyperleukocytosis (white blood cell count, >100×109/l), an uncommon presentation of leukemia, is associated with an increased risk of early mortality. It may present with a variety of symptoms secondary to leukostasis, a syndrome caused by the sludging of circulating leukemic blasts in the microvasculature.