What is a Tikosyn load?
This medication is used to treat certain types of serious (possibly fatal) irregular heartbeat (such as atrial fibrillation/flutter). It is used to restore normal heart rhythm and maintain a regular, steady heartbeat. Dofetilide is known as an anti-arrhythmic drug.
What are some considerations when administering Tikosyn?
Administer the adjusted TIKOSYN dose and begin continuous ECG monitoring. Step 6….Initiation of TIKOSYN Therapy.
|Calculated Creatinine Clearance||TIKOSYN Dose|
|>60 mL/min||500 mcg twice daily|
|40 to 60 mL/min||250 mcg twice daily|
|20 to <40 mL/min||125 mcg twice daily|
|<20 mL/min||Tikosyn is contraindicated in these patients|
How do I start Tikosyn?
TIKOSYN must be initiated in a setting that provides continuous electrocardiographic (ECG) monitoring and in the presence of personnel trained in the management of serious ventricular arrhythmias. Patients should continue to be monitored in this way for a minimum of 3 days.
What drugs are contraindicated with Tikosyn?
The concomitant use of verapamil or the cation transport system inhibitors cimetidine, trimethoprim (alone or in combination with sulfamethoxazole), or ketoconazole with TIKOSYN is contraindicated (see WARNINGS and PRECAUTIONS, Drug-Drug Interactions), as each of these drugs cause a substantial increase in dofetilide …
Is Tikosyn a high risk medication?
As with other drugs that cause Torsade de Pointes, TIKOSYN was associated with a greater risk of Torsade de Pointes in female patients than in male patients. During the TIKOSYN clinical development program, the risk of Torsade de Pointes in females was approximately 3 times the risk in males.
Can you take metoprolol with Tikosyn?
Interactions between your drugs No interactions were found between metoprolol and Tikosyn. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
What is the cost of Tikosyn?
Tikosyn is a brand-name prescription medication used to treat certain types of irregular heartbeat, such as atrial fibrillation. The generic name of this drug is dofetilide. The average retail price of Tikosyn is around $932.91 for 60, 500MCG Capsule.
Is there a generic version of Tikosyn?
Generic version Tikosyn is available in a generic form called dofetilide. A generic drug is an exact copy of the active drug in a brand-name medication.
What tier drug is Tikosyn?
What drug tier is dofetilide typically on? Medicare prescription drug plans typically list dofetilide on Tier 4 of their formulary. Generally, the higher the tier, the more you have to pay for the medication.
Can Tikosyn make you tired?
sleep problems (insomnia), back pain, skin rash, or. cold symptoms such as stuffy nose, sneezing, or sore throat.
Is Tikosyn safe long term?
Nashville, TN – In one of the first studies to look at the long-term effects of dofetilide (Tikosyn? – Pfizer) in patients with left ventricular dysfunction and implantable cardioverter-defibrillators (ICDs), researchers report that the drug likely increases the risk of torsade de pointes.
Can you take Tylenol with Tikosyn?
You can take Tikosyn with acetaminophen (Tylenol) or cold medication. There are no drug interactions between Tikosyn and Tylenol or cold medications. However, some other medications used to treat atrial fibrillation (AFib) or atrial flutter may interact with decongestant drugs.
Are Tikosyn 125 MCG and 250 mcg capsules available?
Yes No TIKOSYN 125 mcg (0.125 mg) capsules are supplied as No. 4 capsules with a light orange cap and white body, printed with TKN 125 PFIZER, and are available in: TIKOSYN 250 mcg (0.25 mg) capsules are supplied…
Can Tikosyn be prescribed in an inpatient setting?
Tikosyn can induce serious ventricular arrhythmias and its label describes the requirement to initiate the drug in an inpatient setting with appropriate monitoring and dose selection. Under the REMS program, Tikosyn (dofetilide) could only be prescribed by enrolled prescribers and dispensed by enrolled pharmacies and healthcare facilities.
What is dofetilide (Tikosyn) used for?
Tikosyn, also called dofetilide, is an antiarrhythmic medication that can help with your Afib. What is Tikosyn? Tikosyn is designed to keep you in sinus (or normal) rhythm or more specifically, keep you out of Afib.
What is the recommended dose of Tikosyn for heart rate monitoring?
(QT interval should be used if the heart rate is <60 beats per minute. There are no data on use of TIKOSYN when the heart rate is <50 beats per minute.) The usual recommended dose of TIKOSYN is 500 mcg BID, as modified by the dosing algorithm described below. For consideration of a lower dose, see Special Considerations below.