What does ADAMTS13 stand for?
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large protein involved in blood clotting.
What is ADAMTS13 inhibitor?
ADAMTS13 is a plasma protein that regulates the interaction of platelets with von Willebrand factor. Absent or low ADAMTS13 activity allows formation of platelet microthrombi, which in turn obstruct arterioles and capillaries, generating the clinical sequelae of TTP.
What does Plasmic score stand for?
Predicts ADAMTS13 deficiency in suspected thrombotic thrombocytopenic purpura (TTP) with high discrimination. Use in hospitalized adult inpatients with suspected thrombotic thrombocytopenic purpura (TTP) who might benefit from early initiation of plasma exchange while awaiting ADAMTS-13 results.
What is Adams TS 13 test?
Tests for ADAMTS13 Antibodies ADAMTS13 Bethesda assays detect antibodies that neutralize function, which are present in approximately two-thirds of TTP cases. These are similar to the traditional Bethesda assays used to detect and titer coagulation factor VIII or IX inhibitors.
What is an Adam 13 test?
ADAMTS13 test distinguishes thrombotic thrombocytopenic purpura (TTP) from other thrombotic microangiopathies (TMAs). PLASMIC score helps determine the pretest probability of ADAMTS13 deficiency.
Where is ADAMTS13 produced?
ADAMTS13 is primarily synthesized in the liver, and its main function is to cleave von Willebrand factor (VWF) anchored on the endothelial surface, in circulation, and at the sites of vascular injury.
What is ADAMTS13 level?
Congenital ADAMTS13 deficiency, also referred to as Upshaw-Schulman syndrome, is an autosomal-recessive disorder that is associated with ADAMTS13 activity levels below the level of detection of activity assays (ie, >10% for the assay used by LabCorp).
Is ADAMTS13 anticoagulant?
As with other coagulation testing, citrated platelet-poor plasma is the specimen of choice for ADAMTS13 testing. EDTA plasma is unacceptable since ADAMTS13 is a metalloproteinase and this anticoagulant strongly chelates metal ions that are necessary for its function.
How can you tell the difference between ITP and DIC?
Thrombocytopenia is present in both DIC and immune thrombocytopenia (ITP). However, ITP is distinct from DIC in terms of its pathophysiologic mechanism and does not involve coagulation activation or microangiopathic hemolytic anemia.
What is Pasmic?
Plasmic is a visual builder for the web. Non-developers can build pages or parts of pages, and developers can integrate these into any website or app codebase. The goal is to empower and unblock non-developers such as marketers and designers, while freeing up developers from pixel-pushing.
When was ADAMTS13 discovered?
DISCOVERY OF ADAMTS13 In 1996, Furlan (13) and Tsai (14) used chromatographic techniques to isolate VWF-cp from normal human plasma with only partial success.