WHO classification uterine sarcomas?

Uterine sarcomas have been classified into two categories: non-epithelial and mixed non-epithelial/epithelial malignancy, dependent on the tissue of origin. The distinction between uterine sarcomas and other uterine tumors is clinically difficult and is reliant on histological and imaging features.

What is the prognosis for uterine sarcoma?

Uterine sarcoma has a poor prognosis, and existing common treatments, such as surgery, radiotherapy, and chemotherapy, are not effective (4). The 5-year survival rate is 50%–55% for patients with early uterine sarcoma and 8%–12% for advanced cases (5, 6). However, few studies have examined patients who died early.

What is the incidence of uterine sarcoma?

Uterine sarcomas are a group of rare neoplasms with an incidence of 3–7 per 100,000 women in the U.S. [2].

What is undifferentiated uterine sarcoma?

The World Health Organization defined undifferentiated uterine sarcoma as a tumour arising in the endometrium or myometrium, lacking any resemblance to proliferative-phase endometrial stroma, with high-grade cytological features and with no specific type of differentiation. The mean age for diagnosis is 60 years [2].

What is stage 4 uterine sarcoma?

Uterine sarcoma stages range from stage I (1) through IV (4). As a rule, the lower the number, the less the cancer has spread. A higher number, such as stage IV, means cancer has spread more. And within a stage, an earlier letter means a lower stage.

What are the stages of uterine sarcoma?

Stages of Uterine Sarcoma stage I: the cancer is only in the uterus. stage II: the cancer is growing outside of the uterus, but not outside the pelvis. stage III: the cancer is growing into the tissues of the abdomen or farther, but has not spread to distant sites.

How quickly does uterine sarcoma grow?

It can grow fast and may even double in size in as little as four weeks. The treatment needs to be initiated as soon as possible after its diagnosis. Even after the treatment, there are high chances that this type of cancer will recur. The signs and symptoms of leiomyosarcoma are nonspecific.

What is the death rate of uterine sarcoma?

Where does uterine sarcoma metastasis?

In the autopsy series of 73 patients with uterine sarcomas by Rose et al. [21] which included 19 patients with ULMS, the most common site of metastases was peritoneal cavity followed by lung, lymph nodes, and liver.

What is high grade endometrial stromal sarcoma?

High-grade endometrial sarcomas are rare and aggressive tumors having a very poor prognosis. Early diagnosis in the initial stages is of paramount importance to increase the overall survival.

Is uterine sarcoma fast growing?

Types of uterine sarcoma These tumors start in the muscular wall of the uterus (the myometrium). They are by far the most common type. These tumors can grow and spread quickly.

Is stage 4 uterine sarcoma curable?

Stage IVB cancers have spread outside the pelvis, most often to the lungs, liver, or bone. There’s no standard treatment for these cancers. Chemo may be able to shrink the tumors for a time, but is not thought to be able to cure the cancer. Radiation therapy, given along with chemo, may also be an option.

Where does uterine sarcoma spread to?

If uterine sarcoma spreads, it tends to first go to places near the uterus. It can spread to the cervix, vagina, ovaries, fallopian tubes, and lymph nodes. In later stages, as it grows, it can spread to the bladder, bowel, lungs, liver, or bone.

Is uterine sarcoma curable?

Uterine sarcoma is curable, especially if it’s low-grade (mildly abnormal cells) and it hasn’t spread beyond your uterus. In some cases, additional treatment, like chemotherapy and radiation, may be needed to destroy the cancer cells completely.

Where does uterine sarcoma metastasize to?

It can spread to the cervix, vagina, ovaries, fallopian tubes, and lymph nodes. In later stages, as it grows, it can spread to the bladder, bowel, lungs, liver, or bone. Cancer that spreads to other parts of the body is called metastatic cancer.

How long does it take for uterine sarcoma to grow?

How serious is uterine sarcoma?

Uterine sarcoma is an extremely rare type of cancer that forms in the muscles or tissues of your uterus. Symptoms include unusual bleeding, pain and feeling full. Treatment may include surgery, radiation, chemotherapy or hormone therapy.