Is clotrimazole soluble in water?
The solubility of CLOT in water at 25° was found to be 5.6 μg/ml, which confirms a previously reported value. On the other hand, the water solubility of clotrimazole was reported as 0.49 mg/l in different test reports[24,25].
What is clotrimazole topical solution used for?
Clotrimazole is an antifungal medicine. It’s used to treat skin infections caused by a fungus (yeast). Clotrimazole treats different types of fungal infections including: athlete’s foot.
Is clotrimazole absorbed through the skin?
Pharmacokinetics. As previously mentioned, clotrimazole has very poor oral bioavailability. Less than 3% is absorbed from mucosal surfaces and less than 0.5% is absorbed through the skin. Most of the absorbed drug is metabolized on first pass through the liver.
Can I use clotrimazole on pubic area?
If you have itching/burning around the outside of the vagina (vulva), apply the skin cream to that area usually once or twice a day for no more than 7 days. If you are using a product with only the vaginal cream, you may apply a small amount of the vaginal cream to the area.
Is clotrimazole hydrophobic?
Clotrimazole Fluidizes Phospholipid Membranes and Localizes at the Hydrophobic Part near the Polar Part of the Membrane. Department of Biochemistry and Molecular Biology (A), Faculty of Veterinary Science, International Campus of Excellence Mare Nostrum, Universidad de Murcia, Apartado.
Is clotrimazole soluble?
Clotrimazole is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of clotrimazole in these solvents is approximately 10, 3, and 20 mg/ml, respectively. Clotrimazole is sparingly soluble in aqueous buffers.
Is clotrimazole solution over the counter?
Clotrimazole topical preparations are used to treat fungus infections on the skin. This medicine is available both over-the-counter (OTC) and with your doctor’s prescription. This product is available in the following dosage forms: Cream.
How do you apply clotrimazole?
Apply enough clotrimazole to cover the affected and surrounding skin areas, and rub in gently. Keep this medicine away from the eyes.
Can I use clotrimazole on my face?
Do not use longer than you have been told by the doctor. Do not put on cuts, scrapes, or damaged skin. Do not use betamethasone and clotrimazole cream on the face or underarms. This medicine may raise the chance of cataracts or glaucoma.
What is the half life of clotrimazole?
Half-life: 3.5-5 hr.
Is clotrimazole a steroid?
What is this medicine? BETAMETHASONE; CLOTRIMAZOLE (bay ta METH a sone; kloe TRIM a zole) is a corticosteroid and antifungal cream. It treats ringworm and infections like jock itch and athlete’s foot.
How is clotrimazole absorbed?
There is minimal systemic absorption following topical application of clotrimazole. Intravaginal Route – roughly 5 to 10% of clotrimazole undergoes absorption following vaginal use. Therefore, fungicidal concentrations can persist in the vagina for up to 3 days after application.
Is clotrimazole good for acne?
Dr. Kim also recommends OTC topical anti-fungal cream, like miconazole or clotrimazole, once or twice daily, but don’t expect overnight results. Malassezia folliculitis can take several weeks to months to improve, so be patient.
Can I use clotrimazole on my foreskin?
Antifungal creams: If a yeast infection is causing balanitis, your provider will prescribe an antifungal cream such as clotrimazole to treat the infection. You will need to apply the cream to the glans (head of the penis) and foreskin as prescribed.