Is p63 an antibody?
p63-α Antibody | Cell Signaling Technology.
What is p63 immunohistochemistry?
Tumor protein 63 (p63) is a transcription factor of the p53 gene family involved in differentiation of several tissues including squamous epithelium. p63 immunohistochemistry is broadly used for tumor classification but published data on its expression in cancer is conflicting.
Is p63 a tumor suppressor?
p63 Expression in Cancer Mutations of p63 are extremely rare in human cancers, indicating it is not a canonical tumor suppressor.
What does positive for p63 mean?
P63: scored positive when high intensity staining was present on ≥50% of tumor cells; the remainder was scored negative [10]. TTF-1: scored positive when staining was present on ≥5% of tumor cells; the remainder was scored negative [11].
What does p63 positive mean in breast?
P63 is a positive prognostic factor in endocrine-treated ER positive breast cancer and might influence responsiveness to endocrine treatment. Thus, p63 could be helpful as a predictive factor for endocrine therapy.
What does p63 positive mean?
What is p63 positive in breast?
What is p63 in breast biopsy?
Abstract. p63, a member of the p53 gene family, is involved in cellular differentiation and is expressed in the nuclei of myoepithelial cells of normal breast ducts and lobules.
What does negative for p63 mean?
Clinical Information. The p63 protein is a member of the p53 family of tumor-suppressor proteins. The predominant localization of p63 protein is in the basal layer of stratified squamous and transitional epithelia. p63 is negative in malignant tumors of the prostate. Striated muscle staining may be observed with p63.
What is a p63 test?
p63, as a marker of myoepithelial and basal cells, is extremely useful in diagnostic surgical pathology, particularly when examining difficult breast biopsies and prostate biopsies. p63 is also a marker of squamous cell and erothelial carcinomas.
What is p63 negative mean?
p63 is negative in malignant tumors of the prostate. Striated muscle staining may be observed with p63. Interpretation. This test does not include pathologist interpretation, only technical performance of the stain.
What does a positive p63 mean?
What is p63 a marker of?
Antibody against p63 is frequently used to aid in the diagnosis of prostate carcinoma, as well as in the identification of myoepithelial cells in other tissues including the breast. p63 is also a marker for squamous cell carcinoma.