What brands are lipophilic statins?
Lipophilic statins include atorvastatin, simvastatin, lovastatin, fluvastatin, and pitavastatin, while hydrophilic statins include rosuvastatin and pravastatin (Schachter, 2005).
What are the brand names of statins?
They include:
- Atorvastatin (Lipitor)
- Fluvastatin (Lescol XL)
- Lovastatin (Altoprev)
- Pitavastatin (Livalo, Zypitamag)
- Pravastatin (Pravachol)
- Rosuvastatin (Crestor, Ezallor)
- Simvastatin (Zocor)
What is the newest statin drug on the market?
Federal regulators have approved the new drug Leqvio to be used to help lower cholesterol levels in some people. The medication is designed to be taken along with statins and a balanced diet. Leqvio is designed to be taken twice a year, which experts say should help people adhere to a medication schedule.
What is the least lipophilic statin?
Pravastatin is not metabolized by the cytochrome P450 system at all and has the lowest risk of drug-drug interactions of all the statins. All in all, pravastatin, fluvastatin and rosuvastatin are much less likely than their lipophilic, CYP3A4 metabolized cousins to be involved in drug-drug interactions.
What is the most hydrophilic statin?
The predominantly lipophilic statins (simvastatin, fluvastatin, pitavastatin, lovastatin and atorvastatin) can easily enter cells, whereas hydrophilic statins (rosuvastatin and pravastatin) present greater hepatoselectivity.
What is the safest medication to lower cholesterol?
Still, all in all, the statins are the safest and best tolerated of all cholesterol-lowering medications. Although most patients respond well to statin therapy, some don’t.
Why are lipophilic statins better?
According to their solubility, statins can be categorised as hydrophilic and lipophilic. The predominantly lipophilic statins (simvastatin, fluvastatin, lovastatin, pitavastatin, and atorvastatin) can easily pass more deeply into the membranes where they interact with the surrounding acyl chains.
Why are hydrophilic statins better?
Is rosuvastatin hydrophilic or lipophilic?
Lipophilic statins include atorvastatin, simvastatin, lovastatin, fluvastatin, cerivastatin and pitavastatin, while hydrophilic statins include rosuvastatin and pravastatin.
