What is mesangial proliferative glomerulonephritis?
Mesangial proliferative glomerulonephritis (MPGN) is a condition that affects the kidneys. It may present with nephrotic syndrome, which is a group of symptoms that include protein in the urine (proteinuria), low blood protein levels, high cholesterol levels, high triglyceride levels, and swelling.
What is IgG nephropathy?
Overview. IgA nephropathy (nuh-FROP-uh-thee), also known as Berger’s disease, is a kidney disease that occurs when an antibody called immunoglobulin A (IgA) builds up in your kidneys. This results in local inflammation that, over time, can hamper your kidneys’ ability to filter waste from your blood.
What is IgM nephropathy?
IgM Nephropathy is an autoimmune disease that affects the filters (gomeruli) of the kidneys. IgM is an immunoglobulin, which is a part of an individual’s healthy immune system. Immunoglobulin M is an antibody produced by B cells and is normally the first antibody to respond and attack an infection in the body.
What is the most common cause of glomerulonephritis?
What causes acute glomerulonephritis? The acute disease may be caused by infections such as strep throat. It may also be caused by other illnesses, including lupus, Goodpasture’s syndrome, Wegener’s disease, and polyarteritis nodosa. Early diagnosis and prompt treatment are important to prevent kidney failure.
What is mesangial nephritis?
Mesangial proliferative glomerulonephritis (MesPGN) is a morphological pattern characterized by a numerical increase in mesangial cells and expansion of the extracellular matrix within the mesangium of the glomerulus.
What are the signs and symptoms of glomerulonephritis?
Glomerulonephritis signs and symptoms may include:
- Pink or cola-colored urine from red blood cells in your urine (hematuria)
- Foamy or bubbly urine due to excess protein in the urine (proteinuria)
- High blood pressure (hypertension)
- Fluid retention (edema) with swelling evident in your face, hands, feet and abdomen.
Is there a cure for IgM nephropathy?
No specific treatment is known to date for this disease because of uncertainties in etiopathogenesis. The mainstay treatment for this disease has been corticosteroids, which has varying degrees of resistance ranging from 0% to 50%.
What is a classic symptom of glomerulonephritis?
Glomerulonephritis signs and symptoms may include: Pink or cola-colored urine from red blood cells in your urine (hematuria) Foamy or bubbly urine due to excess protein in the urine (proteinuria) High blood pressure (hypertension) Fluid retention (edema) with swelling evident in your face, hands, feet and abdomen.
Where are mesangial cells located?
the glomerulus
Mesangial cells are specialised cells in the kidney that make up the mesangium of the glomerulus. Together with the mesangial matrix, they form the vascular pole of the renal corpuscle. The mesangial cell population accounts for approximately 30-40% of the total cells in the glomerulus.
Can you recover from glomerulonephritis?
Children who develop acute glomerulonephritis after a bacterial infection often recover completely. But others—especially those with chronic glomerulonephritis caused by an autoimmune condition—may need ongoing treatment and support.
What causes IgM nephropathy?
What causes IgM nephropathy? Basically no-one knows fully. IgM is part of the body’s defence against infection. As the antibody travels around in the blood and passes through the kidney it can get deposited in the filters (glomeruli) and then can cause an inflammatory reaction.
