What are nitrosating agents?

What are nitrosating agents?

Nitrosating agent means any sub- stance that has the potential to trans- fer a nitrosyl group (–NO) to a primary, secondary, or tertiary amine to form the corresponding nitrosamine.

What are the components of nitrosamines?

Nitrosamines are formed by reaction of secondary or tertiary amines with a nitrosating agent. In foods, the nitrosating agent is usually nitrous anhydride, formed from nitrite in acidic, aqueous solution. Food constituents and the physical make-up of the food can effect nitrosamine formation.

Is nitric acid a nitrosating agent?

Guidance 1 (Sources of nitrosating agents) Nitrosating agents to be considered include; nitrites (e.g. sodium nitrite, NaNO2) and nitrous acid (HNO2), nitric oxide (NO), nitrosyl halides (e.g. ClNO, BrNO), dinitrogen trioxide (N2O3), dinitrogen tetroxide (N2O4) and organic nitrites (e.g. t-BuONO).

Where do you find nitrosamine?

A type of chemical found in tobacco products and tobacco smoke. Nitrosamines are also found in many foods, including fish, beer, fried foods, and meats. Some nitrosamines cause cancer in laboratory animals and may increase the risk of certain types of cancer in humans.

What is nitrosamine risk assessment?

The European Medicines Agency (EMA) has assessed the risk of nitrosamine formation or presence during the manufacture of human medicines and has provided guidance to marketing authorisation holders to avoid the presence of nitrosamine impurities.

Where do you find nitrosamines?

Nitrosamines are organic compounds that we are exposed to in our everyday lives. They exist in low levels in our water and foods, including meat, vegetables, and dairy products. Nitrosamines come from chemical reactions and can form in drugs during manufacturing.

How many types of nitrosamines are there?

seven nitrosamine impurities
FDA has identified seven nitrosamine impurities that theoretically could be present in drug products: NDMA, N-nitrosodiethylamine (NDEA), N-nitroso-N-methyl-4-aminobutanoic acid (NMBA), N-nitrosoisopropylethyl amine (NIPEA), N-nitrosodiisopropylamine (NDIPA), N- nitrosodibutylamine (NDBA), and N- …

How do you reduce nitrosamine?

Vitamin E and selenium have been found to minimize or prevent the reaction of nitrites/nitrates with amines and hence prevent or reduce the formation of carcinogenic nitrosamines. Vitamin C (ascorbic acid) is known to inhibit nitrosamine formation.

At what temperature do nitrosamines form?

Microbial polyamine synthesis following decarboxylation of amino acids provides amine precursors for cyclic N-nitrosamines (N-nitrosopiperidine and N-nitrosopyrrolidine) (11)….Instrument method of GC-PCI-MS/MS.

Column Pre: DB-5ms (5 m × 0.53 mm I.D., 0.25 μm df)
Transfer line temperature 240℃
Source temperature 150℃

Can ammonia form nitrosamines?

to mix aqueous ammonium chloride and sodium nitrite; nitrogen is evolved upon warming the solution. The reaction has been examined mechanistically to some extent, and the reaction is thought to involve nitrosation of the free base form of ammonia present in low concentration [equation (2)].

How do you test for nitrosamines?

How do you test for NDMA? Nitrosamine impurities such as NDMA and NDEA can be analyzed and quantified using gas chromatography or high performance liquid chromatography coupled with an high-resolution mass spectrometer.

Are nitrosamines in plastics?

Nitrosamines or their precursors occur in a wide variety of foods and manufactured and natural products, such as agricultural chemicals, tobacco, detergents, rust inhibitors, cutting fluids, rub- ber additives, solvents, drugs, plastics, tanned leather products, tex- tiles, and cosmetics (ATSDR 1989).

Where is nitrosamine found?

Do condoms have nitrosamines?

Nitrosamines are present in condoms because it helps the latex keep its elasticity. It can be found in tons of things that feature rubber, including baby bottle nipples, balloons, and latex gloves. The researchers found N-Nitrosamine in 29 of 32 condoms they tested.

Do Durex condoms have nitrosamines?

And certain varieties of the major condom brands, including Trojan, Durex and Lifestyles, also are nitrosamine free.

What chemicals should you avoid in condoms?

Nitrosamines: common ingredient in latex condoms linked to cancer. This does NOT mean that you should stop using condoms. Sustain condoms are certified MADE SAFE, but if you don’t happen to have those on hand, use other condoms to protect against STIs and pregnancy. See more on nitrosamines in condoms.

Related Posts