What is Boronate?

What is Boronate?

Noun. boronate (plural boronates) (organic chemistry) Any salt or ester of a boronic acid.

Is boronic acid a nucleophile?

The reaction is also referred to as the Boronic Acid Mannich Reaction, since it proceeds via an imine with the organic ligand of the boronic acid acting as the nucleophile, similar to the role of the enolizable ketone component in the original Mannich Reaction.

What are boronic acids used for?

Boronic acids are used extensively in organic chemistry as chemical building blocks and intermediates predominantly in the Suzuki coupling. A key concept in its chemistry is transmetallation of its organic residue to a transition metal. The compound bortezomib with a boronic acid group is a drug used in chemotherapy.

What is Boronate affinity?

Boronate affinity chromatography (BAC) is commonly used in sample preparation techniques for its specific selectivity for cis-diol-containing compounds. Various chromatographic materials based on phenyl-boronic acid (PBA) functionalization have been designed.

What is Ngsp HbA1c?

The NGSP was established in 1996 to harmonize HbA1c measurements so that routine clinical results would be traceable to those in the DCCT (and subsequently the UKPDS), enabling physicians and patients to achieve glycemic targets recommended by clinical diabetes societies.

What is Boronate affinity HPLC?

Boronate affinity chromatography (BAC) is a unique means for selective separation and enrichment of cis-diol-containing compounds. Cis-diol-containing biomolecules are an important class of compounds, including glycoproteins, glycopeptides, ribonucleosides, ribonucleotides, saccharides, and catecholamines.

How do you make boronic esters?

Boronic esters are esters formed between a boronic acid and an alcohol. The compounds can be obtained from borate esters by condensation with alcohols and diols.

What is IFCC and NGSP?

IFCC results are accuracy-based; NGSP results can be directly related to clinical outcomes and diabetes care goals. Although the IFCC/NGSP correlation is excellent, the absolute numbers are different and there has been much debate over which numbers should be reported worldwide.

What does HbA1c measure?

The A1C test—also known as the hemoglobin A1C or HbA1c test—is a simple blood test that measures your average blood sugar levels over the past 3 months. It’s one of the commonly used tests to diagnose prediabetes and diabetes, and is also the main test to help you and your health care team manage your diabetes.

How do boronic acids form?

Structure and synthesis First, diethylzinc and triethyl borate reacted to produce triethylborane. This compound then oxidized in air to form ethylboronic acid. Several synthetic routes are now in common use, and many air-stable boronic acids are commercially available.

What does IFCC stand for?

What Does International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Mean? The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) is a worldwide professional organization representing the fields of clinical chemistry and laboratory medicine.

What is Ngsp?

The National Glycohemoglobin Standardization Program (NGSP) was implemented to enable laboratories to report DCCT/UKPDS-traceable GHb/HbA1c results. The number of methods and laboratories certified by the NGSP as traceable to the DCCT has steadily increased.

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