What are the disorders of Haemostasis?
The majority of congenital bleeding disorders are due to haemophilia A (factor VIII deficiency), haemophilia B (factor IX deficiency) and von Willebrand disease.
What causes bleeding through the skin?
Bleeding into the skin can occur from broken blood vessels that form tiny red dots (called petechiae). Blood also can collect under the tissue in larger flat areas (called purpura), or in a very large bruised area (called an ecchymosis).
What are symptoms of hemostasis?
- Unexplained and excessive bleeding from cuts or injuries, or after surgery or dental work.
- Many large or deep bruises.
- Unusual bleeding after vaccinations.
- Pain, swelling or tightness in your joints.
- Blood in your urine or stool.
- Nosebleeds without a known cause.
- In infants, unexplained irritability.
What is the most common cause of an abnormality in hemostasis?
Numerous hemostatic abnormalities have been associated with acute and chronic renal disease. The most common abnormalities are defective platelet aggregation, decreased platelet adhesiveness, decreased platelet factor-3 availability, and prolongation of the bleeding time.
What causes skin to break and bleed easily?
As a person ages, the skin becomes less flexible and thinner because there is less fat under the skin. The cushioning effect of the skin decreases as the fat under the skin decreases. These changes, along with skin damage from exposure to the sun, cause blood vessels to break easily.
What is primary hemostasis disorder?
Primary hemostatic disorders are caused by failure of platelet plug formation due to quantitative or qualitative platelet disorders, or due to von Willebrand factor deficiency. Clinical signs of primary hemostatic disorders include petechiae, mucosal hemorrhage, prolonged bleeding at sites of injury.
What is von Willebrand syndrome?
Von Willebrand disease (VWD) is a common inherited condition that can make you bleed more easily than normal. People with VWD have a low level of a substance called von Willebrand factor in their blood, or it does not work very well. Von Willebrand factor helps blood cells stick together (clot) when you bleed.
What does vasculitis of the skin look like?
Common vasculitis skin lesions are: red or purple dots (petechiae), usually most numerous on the legs. larger spots, about the size of the end of a finger (purpura), some of which look like large bruises. Less common vasculitis lesions are hives, an itchy lumpy rash and painful or tender lumps.
Which autoimmune disease affects the skin and blood vessels?
Rheumatoid vasculitis is a condition that causes inflammation of small or medium-sized blood vessels. It happens in some people who have had RA for a long time. It most often affects vessels of the skin, fingers and toes, nerves, eyes, and heart.