What is the difference between ACE inhibitors and ARBs?

ACE inhibitors lower blood pressure by preventing the production of angiotensin II, a substance that narrows the blood vessels, while ARBs reduce the action of angiotensin II to prevent blood vessel constriction.

What is the most commonly prescribed ARB?

Currently, valsartan is the most widely prescribed ARB on the market, followed by losartan. Since both medications are generic and insurance companies frequently cover these drugs, there should be little concern with lack of adherence due to cost.

What is the strongest ARB medication?

Irbesartan has one of the highest bioavailabilities among the ARBs. Irbesartan also exhibits nearly linear dose response with a plateau at 300mg (14, 17, 34). Telmisartan is the longest acting angiotensin II receptor blocker in the market with a mean half-life of 24 hours.

Which is better ACE or ARBs?

ARBs are as effective as ACE inhibitors and have a better tolerability profile. ACE inhibitors cause more angioedema in African Americans and more cough in Chinese Americans than in the rest of the population. ACE inhibitors and most ARBs (except for losartan) increase the risk of gout.

Which is safer ARBs or ACE inhibitors?

Choose ARBs Over ACE Inhibitors for First-line Hypertension Treatment, Large New Analysis Suggests. For first-line treatment of hypertension, angiotensin receptor blockers (ARBs) work as well as angiotensin-converting enzyme (ACE) inhibitors but are safer, according to a head-to-head analysis of the 2 drug classes.

Are ARBs better than calcium channel blockers?

In this nationwide population-based simple hypertension study, administration of ARBs showed superior protection against CV events than CCBs during a 3-year follow-up. Our results suggest that ARBs could be preferred over CCBs as the initial choice of antihypertensive treatment regardless of age in real-world practice.

Why are ARBs preferred over ACE inhibitors?

ARBs are preferred for patients who have adverse reactions to ACE inhibitors. (SOR: A, based on a meta-analysis.) ARBs cause less cough than ACE inhibitors, and patients are less likely to discontinue ARBs because of adverse effects.

Can ARBs cause liver damage?

As a class, the ARBs have been associated with rare instances of acute liver injury that is usually self limited in duration, but varies in clinical expression, being usually hepatocellular but occasional cholestatic in nature.

Who should not take losartan?

Tell your doctor if you are pregnant or plan to become pregnant. Do not take losartan if you are pregnant. If you become pregnant while you are taking losartan, stop taking losartan and call your doctor immediately. Losartan may cause death or serious injury to the fetus when taken in the last 6 months of pregnancy.

Can you take ARB and calcium channel blocker together?

A calcium channel blocker (CCB)/angiotensin receptor blocker (ARB) combination is a rational approach for such an antihypertensive strategy. Benefits of CCB/ARB combination therapy include additive BP-lowering effects and lower incidences of adverse events (AEs).

Is amlodipine better than losartan?

In this study amlodipine proved to be more effective than losartan in achieving the primary end point of reducing mean sitting and standing diastolic and systolic blood pressures, although there was no difference in the percentages of each drug in who reached goal pressure at the initial dosages.