Is suramin water soluble?

Suramin (sodium salt) is soluble in the organic solvent DMSO, which should be purged with an inert gas. It is also soluble in water.

What is the chemical composition of suramin?

C51H40N6O23S6 (Suramin)Suramin / Formula

What is Hexasodium salt?

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM).

What is Suramin used for?

Suramin is used to treat trypanosomiasis and T.b. gambiense. Suramin is available under the following different brand and other names: Suramin sodium.

What class of drug is suramin?

11.13 (protein kinase C) inhibitor, an antinematodal drug and a trypanocidal drug. It is a member of phenylureas, a secondary carboxamide and a naphthalenesulfonic acid. It derives from a naphthalene-1,3,5-trisulfonic acid. It is a conjugate acid of a suramin(6-).

Is suramin toxic?

Suramin is a secondary agent in treatment of Onchocerciasis (river blindness), but because of its toxicity, it is rarely used.

How do you make sodium hexametaphosphate solution?

Sodium hexametaphosphate solution: (1) Dissolve 40.0 g of sodium hexametaphosphate granules [(NaPO 3 ) 6 or NaPO3] in 1 L of distilled or good quality tap water at a temperature not exceeding 100°F.

What is Graham’s salt?

Sodium hexametaphosphate

What is suramin side effects?

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• Cloudy urine.
• crawling or tingling sensation of the skin.
• faintness, especially after missing meals.
• headache.
• increased skin color.
• numbness or weakness in arms, hands, legs, or feet.
• skin rash.
• stinging sensation on skin.

What is sodium hexametaphosphate used for?

Sodium hexametaphosphate (SHMP) is a clean, non-toxic phosphate that is widely used in the food industry and the chemical industry [27,28]. It can be used as a chelating reagent for metal ions, an adhesive, and a swelling reagent [29,30].

Is sodium metaphosphate safe?

Sodium hexametaphosphate is primarily used as an emulsifier, texturizer in many foods and as an anti-staining agent in toothpaste. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

Is sodium phosphate same as sodium hexametaphosphate?

Sodium hexametaphosphate (SHMP) is a salt of composition Na6[(PO3)6]. Sodium hexametaphosphate of commerce is typically a mixture of metaphosphates (empirical formula: NaPO3), of which the hexamer is one, and is usually the compound referred to by this name….Sodium hexametaphosphate.

How do you dilute sodium hexametaphosphate?

Is sodium hexametaphosphate soluble in water?

Physical Properties of Sodium Hexametaphosphate – (NaPO3) Soluble in water, insoluble in organic solvents.