What are the factors affecting dissolution?

Factors that affect the dissolution of a drug product include the intrinsic properties of the API (e.g., solubility, wettability, particle size, surface area, morphology, polymorphs), the formulation composition and characteristics (e.g., excipients, hardness, manufacturing process), and the dissolution method used for …

What is difference between dissolution and disintegration?

Definition. Disintegration is a process of breaking down a substance into tiny fragments to improve its solubility in a solvent. The process is used predominantly in pharmaceutical and chemical industries. Dissolution, on the other hand, is a process through which solutes dissolve in a solvent.

What is dissolution principle?

Dissolution is the process in which a substance forms a solution. Dissolution testing measures the extent and rate of solution formation from a dosage form, such as tablet, capsule, ointment, etc. The dissolution of a drug is important for its bioavailability and therapeutic effectiveness.

How do you increase dissolution?

If you are trying to dissolve a substance, you have three primary avenues to increase the dissolution rate: decreasing the particle size of the solid, increasing the temperature and/or increasing the mixing or stirring rate.

How do you calculate dissolution?

To convert this equation in x = Y-c / m (Y = Abs.) DF: dilution factor is indicate number time to dilute the given solution (10, 100 and 1000). Conc µg/ml: DF * Conc µg/ml to get Conc µg/ml. Conc mg/ml: Conc µg/ml / 1000 to get Conc mg/ml.

What is meant by dissolution of company?

Dissolution of a company is when a company is dissolved by order of a Tribunal, i.e. National Company Law Tribunal (NCLT), after the completion of its winding-up process. The company’s dissolution brings its existence to an end, and its name is struck off by the Registrar of Companies (ROC).

What happens first dissolution or disintegration?

Although it cannot measure the amount of drug released, disintegration is, for IR tablets, the first process before dissolution can occur. Disintegration is a physical process related to the mechanical breakdown of a tablet or granulate particle into smaller particles.

What is the difference between dissolution and disintegration time?

DT (disintegration time) measures the break down time of a dosage form into small granules or particles. Dissolution measures the amount of drug release or dissolve in the media.

What are 3 ways to increase the rate of dissolving?

What is rate of dissolution?

The dissolution rate is defined as the rate or speed at which a drug substance dissolves in a medium.

Why is rate of dissolution important?

Dissolution can play an important role in the clearance of particles from all regions of the respiratory tract. The rate of dissolution depends on surface-related properties such as the surface to volume ratio. The larger the ratio, the faster the rate of dissolution for particles of identical composition.

What is dilution factor in dissolution test?

Dilution factor is defined as: total volume of solution per aliquot volume. Where total volume of solution is: 10.0 + 240.0 = 250.0 mL (volumetric flask.) Note: For multiple dilutions the dilution factor is the product of the dilution factors for each individual dilution.

What happens if a corporation is dissolved?

After a company is dissolved, it must liquidate its assets. Liquidation refers to the process of sale or auction of the company’s non-cash assets. Note that only those assets your company owns can be liquidated. Thus, you can’t liquidate assets that are used as collateral for loans.

Why would you dissolve a company?

Contents. A company can be dissolved for different reasons. It might be voluntarily dissolved by its directors when it is not required any more (even if the company is insolvent) or by Companies House if they believe the company is not carrying on business or in operation.

How dissolution test is performed?

Place the stated volume of the dissolution medium, free from dissolved air, into the vessel of the apparatus. Assemble the apparatus and warm the dissolution medium to 36.5° to 37.5°. Unless otherwise stated, place one dosage unit in the apparatus, taking care to exclude air bubbles from the surface of the dosage unit.