What is dysgerminoma of the ovary?
(DIS-jer-mih-NOH-muh) A type of cancer that begins in germ cells in females. Germ cells are cells that form sperm in males or eggs in females. Dysgerminomas occur most often in the ovaries, but they may also occur in other areas of the body, including the central nervous system.
Are dysgerminoma radiosensitive?
Ovarian dysgerminoma is a highly radiosensitive malignant tumor occurring in young age group. The conventional treatment was total abdominal hysterectomy and bilateral salpingo-oophorectomy followed by radiotherapy.
How is dysgerminoma treated?
Treatment of dysgerminoma may be either:
- total abdominal hysterectomy and bilateral salpingo-oophorectomy followed by radiation therapy or combination chemotherapy; or.
- unilateral salpingo-oophorectomy followed by chemotherapy.
Can Dysgerminoma come back?
Abstract. Ovarian dysgerminoma is a rare type of germ cell tumor. The majority of patient relapses occur within 2 years of diagnosis.
Is Dysgerminoma sensitive to radiotherapy?
First, dysgerminomas are highly responsive to both radiation and platinum-based chemotherapy, so adjuvant therapy for advanced-stage disease and treatment of recurrence are typically very successful.
Why is LDH elevated in Dysgerminoma?
Since LDH is a glycolytic enzyme it may be abundant in dysgerminoma cells. Changes in the permeability of the tumor cell membranes or necrosis of tumor cells may release enzymes into the circulation, but in such cases one should expect other enzymes to be as markedly elevated as LDH.
Does Dysgerminoma produce placental alkaline phosphatase?
Dysgerminomas can produce rises in levels of chorionic gonadotrophin, and the majority are positive for placental alkaline phosphatase (Fig. 29.8E).
Are Dysgerminoma radiosensitive?
What cancers raise LDH?
Increased LDH may also be a prognostic tumor marker in many other solid tumors, including colorectal cancer , nasopharyngeal carcinoma [3, 4], lung cancer [5–7], breast cancer [8, 9], prostate cancer , germ cell cancer [11, 12], and melanoma [13, 14].
What causes LDH levels to rise?
Conditions that can cause increased LDH in the blood may include liver disease, anemia, heart attack, bone fractures, muscle trauma, cancers, and infections such as encephalitis, meningitis, encephalitis, and HIV. LDH is also a non-specific marker of tissue turnover, which is a normal metabolic process.